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A new model to monitor the virological efficacy of antiretroviral treatment in resource-poor countries

dc.creatorColebunders, Robert
dc.creatorLaurence, John
dc.creatorShihab, Hasan M.
dc.creatorSemitala, Fred
dc.creatorLutwama, Fred
dc.creatorBakeera-Kitaka, Sabrina
dc.creatorLynen, Lut
dc.creatorSpacek, Lisa
dc.creatorReynolds, Steven J.
dc.creatorQuinn, Thomas C.
dc.creatorViner, Brant
dc.creatorMayanja-Kizza, Harriet
dc.creatorKamya, Moses, R.
dc.date2012-02-15T10:47:45Z
dc.date2012-02-15T10:47:45Z
dc.date2006
dc.date.accessioned2018-09-04T12:32:55Z
dc.date.available2018-09-04T12:32:55Z
dc.identifierColebunders, R., Kamya, M.R., Laurence, J., Shihab, H.M., Semitala, F., Lutwama, F., Bakeera-Kitaka, S., Lynen, L., Spacek, L., Reynolds, S.J., Quinn, T.C., Viner, B., Mayanja-Kizza, H. (2006). A new model to monitor the virological efficacy of antiretroviral treatment in resource-poor countries. Lancet Infectious Diseases, 6
dc.identifier1473-3099
dc.identifierhttp://hdl.handle.net/10570/429
dc.identifier.urihttp://hdl.handle.net/10570/429
dc.descriptionMonitoring the efficacy of antiretroviral treatment in developing countries is difficult because these countries have few laboratory facilities to test viral load and drug resistance. Those that exist are faced with a shortage of trained staff, unreliable electricity supply, and costly reagents. Not only that, but most HIV patients in resource poor countries do not have access to such testing. We propose a new model for monitoring antiretroviral treatment in resource-limited settings that uses patients’ clinical and treatment history, adherence to treatment, and laboratory indices such as haemoglobin level and total lymphocyte count to identify virological treatment failure, and offers patients future treatment options. We believe that this model can make an accurate diagnosis of treatment failure in most patients. However, operational research is needed to assess whether this strategy works in practice.
dc.descriptionAcademic Alliance Foundation
dc.languageen
dc.publisherElsevier
dc.subjectVirological monitoring
dc.subjectHIV patients
dc.subjectAntiretroviral therapy
dc.subjectVirological efficacy
dc.subjectResource-limited settings
dc.subjectDeveloping countries
dc.subjectHIV/AIDS
dc.subjectCD4 cell count
dc.subjectHighly active antiretroviral therapy (HAART)
dc.titleA new model to monitor the virological efficacy of antiretroviral treatment in resource-poor countries
dc.typeJournal article, peer reviewed


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